But here's what you need to know now. On September 9, 2010, the FDA issued a directive that warnings will be required on the use of gadolinium-based contrast agents. The new warnings on the label refer to the risk of a rare and potentially fatal condition, nephrogenic systemic fibrosis (NSF), if the contrast is given to patients with kidney disease. Three of the GBCAs (Magnevist, Omniscan, and Optimark) will be flagged as being inappropriate for patients with acute kidney injury or chronic severe kidney disease.
The updated label will emphasize the need to screen patients for these types of kidney problems before administering the agent and give health care professionals other guidance regarding its use.
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